Related Experiment Video
Updated: Jun 15, 2026
07:52
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
22.5K
Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study
Ainhoa Indurain1,2, Markus Karlsson3, Anders Fernström1,2
1Departments of Nephrology, Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Summary
Adverse muscle composition (AMC) in chronic kidney disease (CKD) patients is linked to increased mortality risk. Maintaining muscle health may be crucial for better outcomes in CKD management.
Area of Science:
- Nephrology
- Gerontology
- Biomedical Imaging
Background:
- Adverse muscle composition (AMC), characterized by low muscle volume and high fat infiltration, is linked to poor outcomes in chronic kidney disease (CKD).
- Previous studies indicate AMC is associated with increased mortality in general and metabolic disorder populations.
Purpose of the Study:
- To investigate the association between MRI-derived muscle composition and all-cause mortality in UK Biobank (UKB) participants with CKD.
- To identify if AMC is a predictor of mortality in individuals with CKD.
Main Methods:
- Utilized UK Biobank data, identifying participants with CKD (eGFRCystatinC<60 ml/min/1.73m2).
- Quantified thigh muscle volume and fat infiltration (MFI) using MRI, defining AMC based on low muscle volume (z-score <-0.68 SD) and high MFI (>7.69% men, >8.82% women).
- Employed Kaplan-Meier curves and adjusted Cox-regression models to analyze all-cause mortality over a mean follow-up of 3.6 years.
Main Results:
- Included 894 CKD participants (mean age 72.2 years, 52.5% male).
- Prevalence of AMC was 32.3%.
- AMC was significantly associated with higher all-cause mortality (adjusted HR 4.21, p=0.007) compared to normal muscle composition.
Conclusions:
- Adverse muscle composition (AMC) is a significant predictor of increased all-cause mortality in individuals with CKD.
- Identifying AMC highlights a high-risk subgroup within the CKD population.
- Preserving muscle composition could be a key therapeutic target for improving CKD management and patient outcomes.
Related Concept Videos
01:21External Anatomy of the Kidney
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...