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Ultrasound-Guided In-Plane Subclavian Vein Puncture versus Prior Ultrasound and Landmark Technique: A Randomized
David Conrad1, Sven Oliver Schneider1, Samira Beller1
1From the Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg, Saarland, Germany.
Anesthesia and Analgesia
|April 14, 2026
Summary
Ultrasound-guided microconvex in-plane subclavian puncture (MISP) significantly reduces central venous catheterization complications compared to the landmark technique. This improved safety profile may justify the slightly longer procedural time.
Area of Science:
- Medical Procedures
- Ultrasound Guidance
- Vascular Access
Background:
- Central venous catheterization (CVC) of the subclavian vein is a common medical procedure.
- Ultrasound guidance is increasingly recommended for CVC to enhance success rates and minimize complications.
- This study evaluates ultrasound-guided microconvex in-plane subclavian puncture (MISP) against the traditional landmark technique.
Purpose of the Study:
- To compare the efficacy and safety of ultrasound-guided MISP versus the landmark technique for subclavian vein catheterization.
- To assess a composite risk score encompassing various puncture-related complications.
- To determine differences in success rates, complication profiles, and procedural times between the two techniques.
Main Methods:
- A randomized controlled trial involving 101 patients undergoing elective surgery.
- Patients were randomized to either the MISP group or the control (landmark) group after an initial ultrasound prescan.
- The primary endpoint was a composite risk score; secondary endpoints included success and complication rates.
Main Results:
- The MISP group exhibited a significantly lower composite risk score (6.4 ± 5.9) compared to the control group (11.6 ± 10.8).
- Ultrasound-guided MISP showed significantly higher success rates (86%) and reduced arterial puncture risk (1.9%) versus the landmark technique (71% and 12%, respectively).
- Procedural time was longer in the MISP group (mean difference of 5 minutes), but complication rates were significantly lower.
Conclusions:
- Ultrasound-guided MISP significantly decreases complication risks associated with subclavian vein catheterization compared to the landmark method.
- The observed reduction in complications may outweigh the increase in procedural time.
- Further research is recommended to establish MISP as a standard CVC approach.

