Related Experiment Video
Updated: Apr 16, 2026
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
Published on: May 12, 2023
Comparative safety of completion thyroidectomy following lobectomy versus total thyroidectomy in differentiated
Ahmed Ghani1, Lamees M Al Darwashi2, May Y Hajeir2
1School of Medicine, University College Dublin, Dublin, D04 C1P1, Ireland.
Background:
This meta-analysis aimed to evaluate the operative safety of completion thyroidectomy (CT) following lobectomy compared with total thyroidectomy (TT) for differentiated thyroid cancer (DTC).
Methods:
PubMed, Ovid Embase, Cochrane Library, CINAHL, and Web of Science were searched from their respective inception dates to October 2025 (PROSPERO ID: CRD420251178003).
Results:
A total of 43,362 patients from twelve studies were included, of whom 6810 (15.7%) underwent CT. CT was associated with lower odds of transient hypocalcemia (OR = 0.46; 95% CI: 0.34 - 0.63; I2 = 68%) compared with TT, while rates of permanent hypocalcemia (OR = 0.78; 95% CI: 0.61 - 1.01; I2 = 16%), transient recurrent laryngeal nerve injury (OR = 0.99; 95% CI: 0.78 - 1.26; I2 = 30%), permanent recurrent laryngeal nerve injury (OR = 1.12; 95% CI: 0.94 - 1.34; I2 = 0%), and hematoma (OR = 1.34; 95% CI: 0.56 - 3.21; I2 = 0%) were similar.
Conclusions:
Our analysis demonstrated that CT appears to have a similar safety profile when compared with upfront TT in selected DTC patients.
