Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure.

Molecular and cellular biochemistry·2026
Same author

Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications.

Regenerative biomaterials·2026
Same author

The Relationship Between Mindfulness and Learning Burnout Among High School Students: The Chain-Mediating Role of Future Time Perspective and Academic Positive Emotions.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Hyaluronic Acid-Modified Zeolitic Imidazolate Framework as a Drug Carrier for Aesculetin Delivery in Tumor-Targeted Therapy.

ChemMedChem·2025
Same author

Protein conformational transition microenvironment in silk fibroin hydrogels: proliferation and chondrogenesis of encapsulated stem cells.

Regenerative biomaterials·2025
Same author

Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention-Deficit/Hyperactivity Disorder.

Molecular nutrition & food research·2025
Same journal

Corrigendum to "Senescent endothelial cells' response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis" [Acta Biomaterialia 166 (2023) 266-277].

Acta biomaterialia·2026
Same journal

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Acta biomaterialia·2026
Same journal

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function.

Acta biomaterialia·2026
Same journal

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.

Acta biomaterialia·2026
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.7K

Hard tissue organoids: From concept to practice.

Xueqian Xu1, Weijie Zhang1, Jiayao Qian1

  • 1State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, PR China.

Acta Biomaterialia
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Organoids offer promising solutions for hard tissue regeneration, overcoming limitations of traditional methods. This review details their design, construction, applications, and future directions for advanced biomaterials and tissue engineering.

Keywords:
Bone organoidsCartilage organoidsHard tissue regenerationMultidimensional biomimeticsTooth organoids

More Related Videos

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
07:31

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

6.8K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

3.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.7K
Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
07:31

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

6.8K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

3.1K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Hard tissues possess limited self-repair capacity, posing challenges for clinical regeneration.
  • Traditional methods like 2D cultures and animal models have limitations, including donor scarcity and poor recapitulation of native tissue complexity.
  • Organoids, as 3D engineered systems, mimic native tissue structures and functions, offering superior potential for hard tissue healing and regeneration.

Purpose of the Study:

  • To comprehensively review the desired features and design principles of hard tissue organoids.
  • To summarize current strategies for organoid construction and recent advances in their development.
  • To discuss the biomedical applications, challenges, and future directions for hard tissue organoids.

Main Methods:

  • Systematic review of existing literature on hard tissue organoids.
  • Analysis of design and construction strategies for simulating native hard tissue complexity.
  • Evaluation of current applications and future prospects in regenerative medicine and drug screening.

Main Results:

  • Organoid construction for hard tissues is challenging due to the need to simulate intricate structures and mechanical properties.
  • Recent advances have transformed organoids from a concept into tangible research objects for hard tissue regeneration.
  • Diverse biomedical applications are emerging, including drug screening and regenerative therapies.

Conclusions:

  • Hard tissue organoids represent a significant advancement over traditional models, offering potential for improved regeneration strategies.
  • Overcoming challenges in simulating native tissue complexity and mechanical properties is crucial for future development.
  • Further research into multidimensional biomimicry and integrated tissue assembly will drive the translational application of organoids.