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Multimodal imaging for quantifying atrophic lesions in pathologic myopia.

Karolina Motloch1,2,3, Omar Moukadem1,2, Paul Goupillou1,2

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Summary
This summary is machine-generated.

Infrared imaging with OCT B-scan (IR+SD-OCT) demonstrated the highest reliability and agreement for quantifying patchy atrophy in highly myopic eyes. While all modalities correlated, IR+SD-OCT showed superior consistency in measurements.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Patchy atrophy is a common complication in highly myopic (HM) eyes.
  • Accurate quantification of atrophy is crucial for monitoring disease progression and treatment efficacy.
  • Several imaging modalities exist, but their comparative reliability in HM eyes is not well-established.

Purpose of the Study:

  • To evaluate and compare the reliability and agreement of four distinct imaging modalities for quantifying patchy atrophy in highly myopic eyes.
  • To determine which imaging technique offers the most consistent measurements for clinical and research applications.

Main Methods:

  • Manual delineation of atrophy area by two independent graders.
  • Measurement using infrared imaging with OCT B-scan (IR+SD-OCT), blue-light fundus autofluorescence (BAF), ultra-wide-field (UWF) pseudocolor fundus photography (PCFP), and UWF green fundus autofluorescence (GAF).
  • Assessment of intragrader, intergrader, and interdevice agreement using intraclass correlation coefficients (ICC) and correlation analysis.

Main Results:

  • Thirty-two eyes from 30 highly myopic patients were analyzed.
  • IR+SD-OCT exhibited the highest intragrader (ICC=0.998-0.999) and intergrader (ICC=0.999) repeatability.
  • All modalities showed significant correlation (r=0.958-0.995, p<0.001) but differed significantly in atrophy area measurements (p<0.001).
  • PCFP measured the smallest median area (2.14 mm²), while BAF measured the largest (2.90 mm²).
  • Larger lesion size was associated with increased interdevice disagreement.

Conclusions:

  • All evaluated imaging modalities provide reliable measurements of atrophy area in highly myopic eyes.
  • Infrared imaging with OCT B-scan (IR+SD-OCT) demonstrates the strongest interdevice agreement and repeatability.
  • Despite correlation, significant differences in measured atrophy areas exist between modalities, highlighting the importance of modality selection.