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Updated: Apr 16, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
[Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration]
Weike Feng1, Bin Chang1, Chunyang Wang1
1First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou Gansu, 730030, P. R. China.
Objective:
To review research progress of bifunctional biomaterials in the treatment of bone tumors and bone defects in recent years, aiming to provide assistance for the further research of bifunctional biomaterials.
Methods:
A wide range of domestic and international literature on the preparation and properties of novel bifunctional biomaterials in recent years was reviewed, followed by summary and analysis. Carrier-functionalized materials, intrinsically active materials, and immune-engineered materials were summarized respectively, and discussions were conducted from aspects such as anti-tumor effects and controlled drug release.
Results:
Studies have revealed that, unlike traditional biomaterials, the novel bifunctional biomaterials can effectively inhibit the in-situ recurrence of bone tumors through precise drug delivery, external field-responsive tumor killing and immunomodulatory anti-tumor effects. Meanwhile, relying on osteoconduction, osteoinduction, and tissue engineering technologies, they promote new bone formation and bone functional reconstruction in bone defect areas.
Conclusion:
Novel multifunctional biomaterials can inhibit bone tumor cells and promote new bone formation at the site of bone defects.
