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Profiling the tumor-resident microbiota in small cell lung cancer and its influence on clinical outcomes

Wengang Zhang1, Wencheng Zhao1, Li Ye1

  • 1Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Journal of Translational Medicine
|April 14, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
LactobacillusClostridiumSmall cell lung cancerTumor microbiota

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...