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Updated: Apr 16, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Overview of pseudo-acute kidney injury
Ran Jiang1,2, Yafeng Huang1,2, Huijuan Mao1,2
1Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
None:
Acute kidney injury (AKI), a common complication among hospitalized patients, is associated with significant morbidity and mortality. Pseudo-AKI, a condition in which serum creatinine levels meet AKI diagnostic criteria despite a preserved glomerular filtration rate, presents diagnostic challenges. It is frequently misdiagnosed or overlooked in clinical practice, potentially leading to unnecessary interventions or diagnostic delays. Pseudo-AKI is caused by the derangement in pathways of creatinine metabolism and handling, including increased creatinine production, reduced tubular creatinine secretion, sampling or assay interference, and urine extravasation. In this review, we provide an overview of the definition, epidemiology, pathophysiology, mechanisms, diagnosis, and management of pseudo-AKI, with the aim of raising important scientific questions that warrant further exploration.
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