Antioxidant Activity, Phytochemical Characterization, and In Vitro Antitumor Effects of Foam-Mat Dried Mango...

This study investigated the antioxidant, antiproliferative, and antitumor effects of dried mango pulp (DMP) on human colorectal adenocarcinoma (Caco-2) and human osteosarcoma (MG63) cell lines. The mango pulp was dehydrated using the foam-mat drying method, and its bioactive compounds were identified by HPLC, UHPLC-MS, and the Folin-Ciocalteu assay, in addition to an in vitro evaluation of antioxidant capacity. DMP significantly decreased cell viability in a dose- and time-dependent manner, with maximal inhibition at 5 mg/mL after 96 h (78.3% for Caco-2; 72.69% for MG63; p < 0.01-0.001). In addition, DMP increased apoptosis rates (p < 0.05) and reduced colony formation (p < 0.05) of both cell lines. These results suggest that DMP is a rich source of phenolic and carotenoid compounds with remarkable antioxidant activity and antitumor potential, possibly mediated by apoptosis pathways. PRACTICAL APPLICATIONS: Dried mango pulp contains natural compounds with strong antioxidant activity and the ability to slow cell growth and promote cell death in laboratory models of colorectal and bone cancer. These findings suggest it could be explored in the future as a supportive ingredient in health-focused foods or supplements.