Clinically significant interactions between drugs, microbiome, and sex
1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Introduction:
There are multiple interactions between drugs and the human microbiome that can influence drug effects and pharmacokinetics, but few clinical studies have examined the influence of sex on these interactions.
Areas Covered:
Literature for this narrative review was searched in PubMed and Google Scholar without language restrictions and for the time period from 2015 to the present. Focus of the search was on clinical trials and observational studies in the human population.
Expert Opinion:
Current knowledge about the clinically significant effects of microbiomes on drug metabolism and treatment outcomes in humans is very scarce, while the question of sex differences remains unanswered. Both population pharmacokinetic studies, including microbiome composition and sex as covariates, and clinical studies of treatment outcomes will be necessary to fill this knowledge gap.
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