Elevated serum omentin levels correlate with tumor aggressiveness and disease progression in breast cancer patients

Breast cancer remains the most frequently diagnosed malignancy among women globally and a leading cause of cancer related mortality. Despite significant progress in diagnosis and treatment, the disease's heterogeneity continues to challenge effective management. Recent studies suggest that metabolic dysfunction and obesity related factors contribute significantly to breast cancer risk and progression. Among various adipokines secreted by adipose tissue, omentin has emerged as a novel molecule of interest due to its insulin sensitizing and anti-inflammatory properties. This study explores the clinical relevance of serum omentin levels in breast cancer patients by comparing them with healthy controls and examining their correlation with different tumor characteristics. Serum omentin levels were significantly higher in breast cancer patients compared to those with benign breast conditions, which in turn were higher than in healthy controls. The study demonstrated a meaningful association between serum omentin levels and key clinicopathological parameters such as age, BMI, tumor size, lymph node status, tumor grade, and hormone receptor expression, reflecting its possible role in indicating disease severity and tumor biology. The findings may enhance our understanding of the metabolic tumor interface and support the potential of omentin as a diagnostic or prognostic biomarker.