Related Experiment Video
Updated: Apr 16, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Recent progress in understanding ferroptosis mechanisms in infectious diseases
Fei Li1,2, Xiangpeng Chen1,2
1Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
None:
Ferroptosis, characterized by lipid peroxidation and iron-dependent oxidative damage, is a crucial factor in various diseases. Although researchers have extensively characterized ferroptosis in cancer and neurodegenerative disorders, its interaction with pathogenic infections remains underexplored. Recent research indicates that ferroptosis contributes to host cell damage during pathogen invasions, impacting disease outcomes. This review summarizes the characteristics, mechanisms, and regulatory networks of ferroptosis. It delineates the key regulatory steps of ferroptosis during infections caused by various pathogens, including viruses, bacteria, fungi, and parasites. Additionally, it examines changes in host markers and related signaling pathways. Furthermore, this review explores the potential similarities and differences among these pathogens and discusses therapeutic strategies for addressing pathogen-related diseases through ferroptosis-dependent mechanisms.
Related Concept Videos
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Pneumonia II: Pathophysiology
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Inhibitors of Viral Protein Synthesis