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Updated: Apr 16, 2026

Author Spotlight: Exploring Cytoskeletal Dynamics to Unveil Novel Antibiotics Through Innovative Cell-Based Assays
Published on: April 26, 2024
Archaeasins as a promising resource for developing next-generation antibiotics uncovered via deep learning
1Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.
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Fighting against antibiotic resistance has an unexpected ally, archaea. Despite the extensive exploration of antimicrobial peptides in bacteria and eukaryotes, the archaeal domain has been overlooked. A recent study employed deep learning to screen archaeasins. The synthesized versions showed a 93 % success rate against pathogens by depolarizing the cytoplasmic membrane, not the outer membrane. This highlights the promise and deep learning power of archaea for antibiotic discovery and the culture of uncultured archaea.
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