Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

43.7K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
43.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.4K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.4K
Cancer Therapies02:49

Cancer Therapies

10.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Bioplastics01:27

Bioplastics

50
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
50

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetocardiography in the diagnosis of suspected ANOCA: a case series.

Frontiers in cardiovascular medicine·2026
Same author

Silencing of human RNA polymerase I subunit A34 influences multiple cellular processes including rDNA transcription and cell migration.

International journal of biological macromolecules·2026
Same author

Mechanism of Oxygen-Chlorine Potential Interaction During the Ca/Y-Mediated Solid-State Deoxidation of Zirconium.

Materials (Basel, Switzerland)·2026
Same author

BTLA and PD-1 combined with radiotherapy for enhancing antitumor immune response in lung cancer via the regulation of memory B cells to promote T-cell infiltration.

Translational lung cancer research·2026
Same author

Macrophages in lung cancer: principal factors, regulatory mechanisms, and therapeutic opportunities: a narrative review.

Translational lung cancer research·2026
Same author

Immune Infiltration-Related Genes as Potential Biomarkers and Predicted Targets for Renal Allograft Delayed Graft Function and Survival Outcome: An Integrated Machine Learning Approach and Drugs Analysis.

Mediators of inflammation·2026

Related Experiment Video

Updated: Apr 16, 2026

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

16.2K

Biomaterials Based on Bacteria for Cancer Clinical Therapy.

Chongyu Liang1, Xiaoming Sun2, Lingyu Xin3

  • 1Shandong Traditional Chinese Medicine University, Department of Radiation Oncology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, People's Republic of China.

Biomaterials Research
|April 15, 2026
PubMed
Summary
This summary is machine-generated.

Engineered bacteria offer a novel cancer therapy approach, targeting tumors and enhancing conventional treatments. This review explores their mechanisms, synergy with other therapies, and clinical translation for safer, effective anticancer strategies.

More Related Videos

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

10.0K
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.4K

Related Experiment Videos

Last Updated: Apr 16, 2026

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

16.2K
Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

10.0K
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.4K

Area of Science:

  • Oncology
  • Synthetic Biology
  • Microbiology

Background:

  • Cancer presents a significant global health challenge requiring novel therapeutic strategies.
  • Bacterial therapy is reemerging as a promising approach, especially for overcoming resistance to conventional treatments.
  • Engineered bacteria can exploit the tumor microenvironment and act as living therapeutics.

Purpose of the Study:

  • To systematically review the mechanisms of engineered bacteria in exerting antitumor effects.
  • To explore the synergistic potential of bacterial therapy with chemotherapy, radiotherapy, and immunotherapy.
  • To assess the clinical translation landscape, challenges, and future directions of bacterial cancer therapy.

Main Methods:

  • Review of scientific literature on engineered bacterial therapy for cancer.
  • Analysis of mechanisms including direct oncolysis, immunogenic cell death, and immune modulation.
  • Evaluation of synergistic effects with conventional therapies and the role of gut microbiota.

Main Results:

  • Engineered bacteria demonstrate antitumor effects through direct killing, immune stimulation, and microenvironment remodeling.
  • Synergistic potential exists with chemotherapy (prodrug activation, overcoming chemoresistance), radiotherapy (radiosensitization), and immunotherapy (converting "cold" to "hot" tumors).
  • Gut microbiota plays a role in systemic antitumor immunity.

Conclusions:

  • Engineered bacteria represent a transformative strategy for cancer treatment, offering localized drug delivery and immune modulation.
  • Bacterial therapy shows significant promise for synergistic application with standard treatments, enhancing efficacy and overcoming resistance.
  • Further research and clinical translation are crucial for developing safer and more effective bacterially mediated anticancer strategies.