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Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients
Haalah Shaaker1,2, Andrew Davenport3
1King Abdulaziz University, Jeddah, Saudi Arabia.
Summary
Peritoneal dialysis patients with higher protein losses and faster clearance rates consumed more dietary protein. This suggests a link between protein intake and loss in PD patients, impacting nutritional status.
Area of Science:
- Nephrology
- Clinical Nutrition
- Biochemistry
Background:
- Peritoneal dialysis (PD) patients are at risk of malnutrition due to protein loss in dialysate.
- Understanding the relationship between dietary protein intake (DPI) and protein loss is crucial for managing PD patients' nutritional status.
Purpose of the Study:
- To investigate the association between dietary protein intake and protein losses in patients undergoing peritoneal dialysis.
Main Methods:
- Dietary protein intake (DPI) was assessed using 24-hour dietary recalls analyzed with Nutrics software.
- Total protein losses were quantified through 24-hour collections of spent dialysate and urine.
Main Results:
- Only 31.7% of the 41 PD patients studied met the recommended DPI target (≥1.0 g/kg/day).
- Patients with higher DPI exhibited significantly greater peritoneal protein losses (5.2 ± 2.4 g/day vs. 3.3 ± 1.1 g/day) and faster peritoneal solute transfer rates.
- Multivariate analysis indicated that DPI was associated with calorie intake and peritoneal protein clearance rate.
Conclusions:
- Patients with increased peritoneal protein clearance and losses demonstrated higher dietary protein intake.
- The findings highlight a correlation between protein turnover and intake in PD patients, suggesting implications for nutritional management strategies.
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