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Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

SERS-Based Nano- and Microsystems Toward Biomedical Applications.

Gohar Soufi¹, Tijana Maric¹, Isidro Badillo-Ramírez¹

¹Center For Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Lyngby, Kongens, Denmark.

Small (Weinheim an Der Bergstrasse, Germany)

|April 15, 2026

Summary

This summary is machine-generated.

Surface-enhanced Raman spectroscopy (SERS) offers sensitive molecular detection for biomedical applications. This review details recent SERS devices and highlights challenges for clinical translation.

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Area of Science:

Analytical Chemistry
Materials Science
Biomedical Engineering

Background:

Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique for sensitive molecular detection.
Advances in nanomaterials and instrumentation have spurred SERS platform development for biomedical sensing.
Clinical translation of SERS technology is hindered by a need for systematic evaluation under relevant conditions.

Purpose of the Study:

To provide a comprehensive overview of nano- and microscale SERS devices reported since 2020.
To highlight advancements in SERS-active architectures, fabrication, and instrumentation.
To discuss challenges and opportunities for the biomedical translation of SERS technology.

Main Methods:

Review of SERS-based nano- and microscale devices published since 2020.
Analysis of material design, fabrication strategies, and instrumentation.
Evaluation of analytical performance in model biological environments.

Main Results:

Overview of controlled SERS architectures: patterned substrates, nanorods, microspheres, micromotors, microneedles, and microfluidic systems.
Summary of fabrication methods, instrumentation, and platform capabilities.
Discussion of static and dynamic SERS platforms for on-site molecular detection.

Conclusions:

SERS technology shows significant potential for biomedical sensing applications.
Key challenges for clinical translation include reproducibility, sample handling, standardization, and integration.
This review serves as a guide for designing SERS systems and identifies future research directions.