Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response.

eLife·2026
Same author

PARP inhibitors induce a senescence phenotype in non-small cell lung carcinoma cell lines.

FEBS open bio·2026
Same author

Three-year insights from a proton therapy centre: Evolving strategies in ependymoma treatment planning.

Technical innovations & patient support in radiation oncology·2025
Same author

Rotifers in space: transcriptomic response of the bdelloid rotifer Adineta vaga aboard the International Space Station.

BMC biology·2025
Same author

Targeting ATF6α Attenuates UVB-Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression.

Aging cell·2025
Same author

AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity.

Autophagy·2024

Related Experiment Video

Updated: Apr 16, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.8K

Gold Nanoparticles Combine with Radiation Therapy to Drive Immunogenic Macrophage Reprogramming.

Shalini Iyer1,2, Tijani Tabarrant3, Benjamin Ledoux4

  • 1Physics Department, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur 5000, Belgium.

ACS Applied Bio Materials
|April 15, 2026
PubMed
Summary

Gold nanoparticles (AuNPs) enhance X-ray radiotherapy by repolarizing tumor-associated macrophages (TAMs) to a cancer-fighting M1 phenotype. This approach improves treatment efficacy for solid tumors like pancreatic cancer.

Keywords:
ROSX-ray radiationgold nanoparticlesmacrophagespancreatic cancerproton radiationradiotherapy

More Related Videos

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.5K
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

12.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.8K
Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.5K
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

12.1K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Heavy-metal-based nano-objects show potential as radiosensitizers.
  • Reactive oxygen species (ROS) amplification is a key mechanism.
  • Repolarizing M2 macrophages to M1 phenotype can enhance anti-cancer responses.

Purpose of the Study:

  • To investigate gold nanoparticles (AuNPs) as radiosensitizers.
  • To evaluate AuNPs' effect on macrophage polarization and cancer cell survival.
  • To assess the combination of AuNPs with X-ray or proton irradiation for pancreatic cancer therapy.

Main Methods:

  • Utilized 15 nm and 50 nm AuNPs coated with PVP or PEG.
  • Exposed M2 macrophages and pancreatic cancer cells to X-ray or proton irradiation with or without AuNPs.
  • Assessed M1 gene expression, macrophage polarization, and cancer cell survival.

Main Results:

  • AuNPs upregulated M1 gene expression and favored M1 polarization with X-ray irradiation.
  • Proton irradiation did not show the same polarization effect.
  • 50 nm PVP-coated AuNPs reduced M2 macrophage survival when co-cultured with pancreatic cancer cells, especially with X-ray therapy.

Conclusions:

  • AuNPs combined with X-ray radiotherapy can repolarize tumor-associated macrophages (TAMs) to a cytotoxic M1 phenotype.
  • This strategy enhances radiotherapy efficacy against pancreatic cancer.
  • Presents an efficient method for improving solid cancer treatment.