Related Experiment Video
Updated: Apr 16, 2026

Author Spotlight: In Vitro Co-Culture System of Pine Shoots and Pinewood Nematode for Studying Host Volatile Response
Published on: September 27, 2024
New Diketopiperazine Alkaloids From the Tuber of Pinellia Ternata (Thunb.) Breit
Shu-Jun Zhang1,2, Yi-Qiang Zhang1,2, Lei-Xin Zhuang1,2
1Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Harbin, China.
Abstract:
Three (1-3) new diketopiperazine alkaloids, two (4-5) new natural products, together with thirteen (6-18) known alkaloids were isolated from Pinellia ternata (Thunb.) Breit. The structures of these compounds were determined by spectral data, and their absolute configurations were determined by DP4+ analysis and ECD calculation. The activity of all compounds was evaluated by the LPS + ATP-induced BEAS-2B cells model. In the evaluation of anti-inflammatory activity, compounds 1 and 3 showed significant activity against BEAS-2B cells, with EC50 values of 1.95 ± 0.17 and 2.60 ± 0.15 µM. Molecular docking and dynamic simulation analyses indicated that compound 1 may potentially target the TLR4 protein.
More Related Videos
09:36Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Anthelminthic Agents
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
Physical Properties of Amines
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Drugs that Destabilize Microtubules