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Updated: Apr 16, 2026
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Parkinson Disease imposes Risk of Kidney Function Decline.
Ryunosuke Mitsuno1, Hidehiro Kaneko2,3, Yuta Suzuki2,4
1Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Summary
Parkinson disease significantly increases the risk of kidney function decline. Adults with Parkinson disease require closer kidney monitoring to prevent adverse outcomes.
Area of Science:
- Nephrology
- Neurology
- Epidemiology
Background:
- Parkinson disease (PD) is linked to systemic issues, but its effect on kidney function is not well-understood in the general population.
- Previous research has not clearly established the association between Parkinson disease and kidney function decline.
Purpose of the Study:
- To investigate the association between Parkinson disease and the risk of kidney function decline.
- To analyze kidney function outcomes in a large, population-based cohort with and without Parkinson disease.
Main Methods:
- Retrospective cohort study utilizing nationwide claims and health checkup data.
- Classified individuals based on Parkinson disease diagnosis using ICD-10 codes.
- Defined composite kidney outcome as end-stage kidney disease, kidney replacement therapy, or a ≥30% decline in estimated glomerular filtration rate (eGFR).
Main Results:
- The study included 1,659,421 individuals, with 11,497 diagnosed with Parkinson disease.
- Over a median follow-up of 1,092 days, Parkinson disease was independently associated with a 1.91-fold increased risk of composite kidney outcome (95% CI, 1.72-2.12).
- Kaplan-Meier analysis indicated a significantly higher risk of kidney function decline in individuals with Parkinson disease.
Conclusions:
- Parkinson disease is independently associated with an increased risk of kidney function decline.
- These findings highlight the need for enhanced kidney function surveillance in adults diagnosed with Parkinson disease.
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