Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lethal Alleles

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

Drug Toxicity: Risk factors

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

Bias in Epidemiological Studies

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Brazilian Dialysis Survey 2024.

Jornal brasileiro de nefrologia·2026

Same author

Brazilian Dialysis Survey from 1999 to 2024: Trends in Dialysis Modalities and Funding.

Kidney360·2026

Same author

Trends in the Prevalence and Incidence of Chronic Dialysis in Brazil (2006-2024) With Projections to 2039.

Hemodialysis international. International Symposium on Home Hemodialysis·2025

Same author

Association between stress hyperglycemia and acute kidney injury requiring dialysis in critically ill patients with sepsis: a hospital-based cohort study.

Jornal brasileiro de nefrologia·2025

Same author

Brazilian Dialysis Survey from 1999 to 2023: trends in demographics, nutritional status, primary disease, and viral serology.

Jornal brasileiro de nefrologia·2025

Same author

The influence of hospital type (public versus private) on mortality and survival after stroke.

Arquivos de neuro-psiquiatria·2025

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Risk factors associated with dengue lethality: case-control study, Joinville, Brazil.

Romana Pedott Apel¹, Saulo Vicente Rocha², Dorceli Alves Lemes da Cruz²

¹Universidade da Região de Joinville, Departamento de Ciências Biológicas, Joinville, SC, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical

|April 15, 2026

Summary

This summary is machine-generated.

Early intravenous hydration and frequent medical check-ups significantly reduced dengue mortality in Joinville, Brazil. Monitoring patients with warning signs is key to improving outcomes in high-incidence areas.

More Related Videos

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

Related Experiment Videos

Last Updated: Jun 17, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

Area of Science:

* Public Health
* Infectious Diseases
* Clinical Medicine

Background:

* Dengue poses a significant public health threat in Brazil, with Joinville experiencing high incidence rates.
* Understanding factors influencing dengue mortality is crucial for targeted interventions in Joinville.

Purpose of the Study:

* To identify clinical and demographic factors associated with dengue-related mortality in Joinville, Brazil.
* To evaluate the impact of medical consultations and intravenous hydration on dengue patient outcomes.

Main Methods:

* Retrospective matched case-control study utilizing the Sistema de Informação de Agravos de Notificação database.
* Inclusion of adult dengue patients with warning signs or severe disease treated in Joinville's public health system (2021-2024).
* Logistic regression models employed to determine mortality risk factors.

Main Results:

* Lower mortality linked to ≥ 2 medical consultations (OR=0.20) and ≥ 1 L intravenous hydration (OR=0.32).
* Significant mortality predictors included hypotension (OR=3.06), thrombocytopenia (OR=2.47), and lethargy/irritability (OR=15.59).
* Analysis included 116 fatal cases and 336 matched survivors.

Conclusions:

* Early intravenous rehydration and consistent clinical evaluations are associated with reduced dengue mortality.
* Close patient monitoring, especially for those with warning signs, is vital for improving survival rates in dengue-endemic regions.