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Different brain spatial metabolic patterns characterizing different subtypes of multiple system atrophy.

Tiffany Carther-Krone1,2, Jarrad Perron2,3, Chong Sik Lee4

  • 1Department of Human Anatomy and Cell Science, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

Journal of Parkinson'S Disease
|April 15, 2026
PubMed
Summary
This summary is machine-generated.

This study reveals distinct brain metabolic patterns and dopamine transporter loss in Multiple System Atrophy (MSA) subtypes. These patterns, along with disease progression, vary by sex and age in MSA-P and MSA-C patients.

Keywords:
MSA-CerebellarMSA-Parkinson'smetabolic patternmultiple system atrophy

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Multiple system atrophy (MSA) is a neurodegenerative disease with parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes.
  • Understanding subtype-specific brain changes is crucial for diagnosis and treatment.

Purpose of the Study:

  • To characterize spatial patterns of brain metabolism using PET scans in MSA subtypes.
  • To assess the relationship between metabolic patterns, striatal dopamine transporter (DAT) loss, and clinical factors like sex, age, and disease duration.

Main Methods:

  • Studied 270 MSA patients using 18F-flurodeoxyglucose-PET and 18F-fluoro-propyl-β-CIT-PET.
  • Applied scaled subprofile modeling (SSM) to identify subtype-specific metabolic patterns (MSAPRP and MSACRP) and quantify DAT loss.

Main Results:

  • Identified distinct metabolic patterns for MSA-P (MSAPRP) and MSA-C (MSACRP).
  • MSA-P showed greater DAT loss than MSA-C. Metabolic patterns and DAT loss correlated with age and disease duration, with sex-specific differences observed.
  • MSAPRP-Combined exhibited hypermetabolism in pons, cerebellum, pallidum, and sensorimotor cortex, with hypometabolism in putamen and other regions. MSACRP showed hypometabolism in cerebellum and putamen.

Conclusions:

  • Brain metabolic and dopaminergic changes in MSA subtypes are distinct and influenced by age and sex.
  • These findings highlight the complex interplay of metabolic alterations, dopaminergic deficits, and clinical variables in MSA progression.