Related Experiment Video

Updated: Apr 16, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Emerging trends and research frontiers in refractory asthma: a comprehensive bibliometric analysis from 2004 to 2025

Xun Xu¹, Shiyuan Gao¹, Zhengjun Huang¹

¹Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma

|April 15, 2026

Abstract

Objective:

Refractory asthma remains a significant challenge in respiratory medicine, requiring advanced therapeutic strategies and precision medicine approaches. Bibliometric analysis provides insights into research trends, key contributors, and evolving frontiers in this field.

Methods:

The present study conducted a bibliometric analysis using data from the Web of Science Core Collection (WoSCC) databases. The included articles between 2004 and 2025 were analyzed scientifically and quantitatively using R 4.3.3, CiteSpace (V 6.3.R1) and VOSviewer (V 1.6.20).

Results:

A total of 711 eligible publications were analyzed, with 4,253 authors from 2,824 institutions across 49 countries/regions contributing to this field. The United States, the United Kingdom, and China were the most productive countries. The University of Newcastle, the University of Leicester, and Université Paris Cité emerged as leading institutions. The Journal of Allergy and Clinical Immunology had the highest publication count and impact. Keyword cluster analysis identified three themes: clinical and epidemiological aspects, immunological mechanisms, and biologic therapies and clinical trials. Emerging research hotspots include "guidelines," representing future trends.

Conclusions:

This study identifies the main research hotspots in refractory asthma, including clinical and epidemiological aspects, immunological mechanisms, and biologic therapies and clinical trials. Future trends in refractory asthma research emphasize guideline-informed precision medicine, integrating biomarkers, digital tools, and individualized treatment strategies to enhance care standardization and effectiveness.

Keywords:

CiteSpace Refractory asthma VOSviewer bibliometric analysis

More Related Videos

Conducting Respiratory Oscillometry in an Outpatient Setting

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Related Concept Videos

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Antiasthma Drugs: β2-Adrenoceptor Agonists

Antiasthma Drugs: β₂-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...

Drugs Used in Lower Respiratory Disorders: Overview

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

Articles linked to this work by shared authors, journal, and citation graph.

Aberrant cerebral iron deposition mediates cognitive dysfunction in obstructive sleep Apnea: evidence from a severity-stratified QSM study.

Sleep·2026

Post Hoc Analysis of Solriamfetol Efficacy in Obstructive Sleep Apnea Patients with Excessive Daytime Sleepiness Stratified by Disease Severity.

Advances in therapy·2026

High-Flow Nasal Cannula in Hypercapnic Respiratory Failure: An Updated Systematic Review and Meta-Analysis.

The clinical respiratory journal·2026

Structurally Driven, Reversible Topological Phase Transition in a Distorted Square Net Material.

Physical review letters·2026

Construction of a severity prediction model for hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease based on machine learning.

European journal of medical research·2025

Solriamfetol for the treatment of excessive daytime sleepiness in participants with obstructive sleep apnea with different levels of adherence to primary OSA therapy: Subgroup analysis of a randomized clinical trial.

Sleep medicine·2025

See all related articles