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Traditional Chinese Medicine Targeting Ferroptosis in Cardiovascular Diseases: Advances and Perspectives
Jianing Wang1, Yuetong Li2, Yuan Liu1
1School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Insights
Ferroptosis, a cell death process linked to cardiovascular diseases (CVDs), involves iron and lipid peroxidation. Traditional Chinese Medicine (TCM) shows promise in targeting ferroptosis pathways for CVD treatment.
Area of Science:
- Cardiovascular Medicine
- Cell Biology
- Pharmacology
Background:
- Ferroptosis, characterized by lipid peroxidation and redox imbalance, is an iron-dependent regulated cell death implicated in cardiovascular diseases (CVDs).
- Ferroptosis contributes to CVD pathogenesis by disrupting iron homeostasis, increasing oxidative stress, and impairing mitochondrial function.
- Traditional Chinese Medicine (TCM) offers a promising therapeutic avenue due to its multi-component, multi-target approach with low toxicity.
Purpose of the Study:
- To review the current understanding of ferroptosis in the context of CVDs.
- To elucidate the mechanisms through which TCM and its constituents modulate ferroptosis pathways.
- To explore the therapeutic potential and translational challenges of TCM-based ferroptosis interventions for CVDs.
Main Methods:
- Comprehensive literature review of ferroptosis in CVDs.
- Analysis of TCM's mechanisms in modulating ferroptosis.
- Discussion of therapeutic implications and translational challenges.
Main Results:
- Ferroptosis plays a significant role in the development and progression of various cardiovascular pathologies.
- TCM exhibits unique potential in regulating ferroptosis-related pathways through its diverse bioactive compounds.
- Understanding these mechanisms can guide the development of novel therapeutic strategies.
Conclusions:
- Ferroptosis is a key factor in CVD pathogenesis, offering a novel therapeutic target.
- TCM provides a valuable framework for developing ferroptosis-targeting interventions for cardiovascular diseases.
- Further research is needed to overcome translational challenges and fully realize TCM's potential in CVD treatment.
Abstract:
Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation and redox imbalance, has recently garnered significant attention for its critical role in the pathogenesis of cardiovascular diseases (CVDs). Accumulating evidence suggests that ferroptosis contributes to a range of cardiovascular pathologies by disturbing iron homeostasis, promoting oxidative stress, and impairing mitochondrial function. Traditional Chinese medicine (TCM), with its multi-component and multi-target properties and relatively low toxicity, has shown unique therapeutic potential in modulating ferroptosis-related pathways. This review provides a comprehensive summary of the current understanding of ferroptosis in CVDs and highlights the mechanisms by which TCM and its bioactive constituents influence ferroptosis. We further discuss the therapeutic implications and translational challenges, aiming to provide novel insights into ferroptosis-targeted interventions for CVDs from the perspective of TCM.
