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Outcomes of ME/CFS following infectious mononucleosis: seven-year follow-up of a prospective study.

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Comparing ME/CFS following mononucleosis with Long COVID.

Leonard A Jason1, Jacob Furst2, Ben Z Katz3

  • 1The Center for Community Research, DePaul University, Chicago, IL, USA.

Chronic Illness
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Summary

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) share similarities as post-infectious illnesses. Long COVID symptom burden falls between moderate and severe ME/CFS cases.

Keywords:
Epstein-Barr virusLong COVIDME/CFSProspectiveSARS-CoV-2infectious mononucleosis

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Area of Science:

  • Post-viral syndromes
  • Infectious disease research
  • Chronic illness studies

Background:

  • Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic illnesses following infections.
  • The underlying mechanisms of ME/CFS post-infectious mononucleosis (IM) and Long COVID post-SARS-CoV-2 are not well understood.

Purpose of the Study:

  • To compare and contrast ME/CFS following IM with Long COVID following SARS-CoV-2 infection.
  • To investigate somatic symptoms, coping strategies, psychological distress, and functional status in these post-viral conditions.

Main Methods:

  • Studied ME/CFS development in college students after IM.
  • Recruited a matched sample of SARS-CoV-2 infected individuals, including those with Long COVID.
  • Compared symptom burden, coping, depression, anxiety, and function between groups.

Main Results:

  • The symptom burden in Long COVID was generally less severe than in severe ME/CFS but more severe than in moderate ME/CFS.
  • Somatic symptoms, coping strategies, depression, anxiety, and functional status were compared across the conditions.

Conclusions:

  • Findings offer insights into the pathophysiologies of post-viral illnesses like ME/CFS and Long COVID.
  • Understanding these conditions can aid in developing targeted diagnostic and therapeutic strategies.