Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

72
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
72
Cancer Survival Analysis01:21

Cancer Survival Analysis

853
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
853
Genetic Lingo01:11

Genetic Lingo

118.9K
Overview
118.9K
Cancer Prevention02:59

Cancer Prevention

3.1K
3.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

10.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.4K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

95
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
95

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.

Science advances·2026
Same author

Addressing the Psychosocial Gap in Hereditary Cancer Care: The Case for Genetic Social Work.

JCO oncology practice·2026
Same author

Cascade Genetic Testing Among Relatives at Risk for Lynch Syndrome: A Systematic Review and Meta-Analysis.

JCO oncology practice·2026
Same author

Outcomes of Type B Dissection in Marfan Syndrome: The Cornell Aortic Aneurysm Registry.

Journal of the American Heart Association·2026
Same author

Differences in Cancer Patient Experience by Race, Ethnicity, and Preferred Language: A Systematic Review.

Cancer medicine·2026
Same author

Reliability and Validity of Patient Ratings and Clinician Self-Report in the Assessment of Clinician Non-English Language Skills.

Journal of general internal medicine·2026

Related Experiment Video

Updated: Apr 17, 2026

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

215

Translating Cancer Genetics Care: Digital Tools to Improve Cancer Genetics Risk Assessment for Patients With Limited

Isabelle R Chandler1, Melissa K Frey1,2, Emily Webster1

  • 1Division of Obstetrics and Gynecology, Division of Gynecologic Oncology, Weill Cornell Medicine, New York, NY.

JCO Oncology Practice
|April 15, 2026
PubMed
Summary
This summary is machine-generated.

A digital cancer genetics risk assessment tool was acceptable to 65% of patients. Spanish speakers showed similar engagement as English speakers, but Chinese speakers had lower interest and completion rates in this study.

More Related Videos

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

16.6K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.4K

Related Experiment Videos

Last Updated: Apr 17, 2026

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

215
Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

16.6K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.4K

Area of Science:

  • Genetics
  • Public Health
  • Digital Health

Background:

  • Limited English proficiency (LEP) poses a barrier to accessing cancer genetics risk assessment (CGRA).
  • Digital tools offer a potential solution for delivering CGRA in linguistically diverse populations.
  • Urban gynecology clinics serve a diverse patient population, making them ideal settings for assessing tool acceptability.

Purpose of the Study:

  • To evaluate the acceptability of a multilingual, digital CGRA tool.
  • To assess patient interest and completion rates across different language groups (English, Spanish, Chinese).
  • To identify potential disparities in the use of digital health tools among diverse patient populations.

Main Methods:

  • A digital CGRA tool was offered to patients at check-in at urban gynecology clinics.
  • The tool assessed personal and family health histories to determine genetic testing eligibility.
  • Patient interest and completion rates were compared across English, Spanish, and Chinese-speaking groups using statistical analyses.

Main Results:

  • Overall, 64.8% of patients initiated and 75.0% completed the digital CGRA tool.
  • Spanish-speaking patients demonstrated similar interest (65.7%) and completion rates (91.3%) compared to English speakers (80.0% and 82.1%).
  • Chinese-speaking patients showed significantly lower interest (48.6%) and completion rates (41.2%) compared to English speakers.

Conclusions:

  • The digital CGRA tool is an acceptable method for assessing cancer genetics risk in diverse patient populations.
  • While acceptable to Spanish speakers, the tool's lower engagement among Chinese speakers highlights a need for further optimization.
  • Future research should focus on improving the accessibility and usability of digital health tools for all linguistic groups.