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Updated: Apr 17, 2026
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymphatic Complications in Congenital Heart Disease
Danish Vaiyani1, Mudit Gupta1, Aaron G DeWitt2
1Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Seminars in Roentgenology
|April 15, 2026
Summary
Lymphatic disease involves abnormal lymph flow, often seen with congenital heart disease, particularly single ventricle defects. Understanding these connections clarifies the disease
Area of Science:
- Cardiovascular Science
- Lymphatic Physiology
Background:
- Lymphatic disease is characterized by abnormal lymph perfusion into body compartments.
- Congenital heart disease (CHD), especially single ventricle CHD, frequently coexists with lymphatic disease.
Purpose of the Study:
- To elucidate the pathophysiology of lymphatic disease in the context of congenital heart disease.
- To explore the interplay between lymphatic and circulatory systems in CHD patients.
Main Methods:
- Physiologic principles of lymphatic and circulatory systems were reviewed.
- Impact of congenital heart disease on these systems was analyzed.
Main Results:
- Abnormal lymph flow can affect various body compartments.
- The co-occurrence of lymphatic disease and CHD highlights complex physiological interactions.
Conclusions:
- Understanding the integrated physiology of the lymphatic and circulatory systems is crucial.
- Appreciating these interactions is key to understanding lymphatic disease pathophysiology in CHD.
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