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Updated: May 7, 2026

Depletion of Specific Cell Populations by Complement Depletion
Published on: February 5, 2010
A fast way to lose antibodies
Sheenam Verma1, Oliver J Harrison2
1Benaroya Research Institute, 1201 9(th) Ave, Seattle, WA 98101, USA.
Abstract:
Long-lived plasma cells maintain antibody titers that sustain humoral immunity, yet the physiological cues regulating their persistence remain incompletely understood. In this issue of Immunity, Zhu et al. reveal that fasting-induced β-hydroxybutyrate destabilizes bone marrow plasma cell niches through HCAR2 signaling, accelerating the loss of long-lived plasma cells and humoral immunity.
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