Related Experiment Video
Updated: Jul 3, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
Published on: March 15, 2019
Universal vaccines? Only if your antibody genes agree
Vishal N Rao1, Camila H Coelho2
1Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract:
Designing a universal influenza vaccine must address not only viral antigenic drift but also genetic variability in human antibody responses. In this issue of Immunity, two studies from the Karlsson-Hedestam lab (Corcoran et al. and Fischer et al.) integrating immunoglobulin (IG) genotyping with antibody sequencing prompt a critical question: have we fully explored how ancestry-specific IG genotypes shape epitope targeting and influence the feasibility of germline-targeting vaccine strategies?
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