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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

Updated: Apr 17, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After TAVR: The GASS-TAVR Study.

Carlo Fumagalli1, Samuele Baldasseroni2, Chiara Fraccaro3

  • 1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

JACC. Cardiovascular Interventions
|April 15, 2026
PubMed
Summary

A new geriatric score accurately predicts 1-year mortality or functional decline in older adults undergoing transcatheter aortic valve replacement (TAVR). This tool aids in selecting appropriate candidates and preventing futile procedures.

Keywords:
TAVRaortic stenosiscomprehensive geriatric assessmentoutcome

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Area of Science:

  • Geriatric Medicine
  • Cardiology
  • Surgical Risk Assessment

Background:

  • Many older adults undergoing transcatheter aortic valve replacement (TAVR) do not experience significant clinical benefits within one year.
  • Improved risk stratification is crucial for optimizing outcomes in this patient population.

Purpose of the Study:

  • To develop and validate a comprehensive geriatric assessment-based score.
  • The score aims to predict 1-year mortality or significant functional decline in elderly TAVR candidates.

Main Methods:

  • A multicenter cohort study included 562 patients aged 75 years or older evaluated for TAVR.
  • A geriatric assessment, including basic activities of daily living (BADL) and nutritional status, was performed.
  • A logistic regression model derived a risk score, validated across derivation and validation cohorts.

Main Results:

  • The primary outcome occurred in 13.9% of patients within 11 months.
  • Key predictors included Mini Nutritional Assessment-Short Form score, BADL, estimated glomerular filtration rate, and pulmonary artery systolic pressure.
  • The derived geriatric score demonstrated high predictive accuracy (AUC 0.92) and outperformed the Society of Thoracic Surgeons score in validation (AUC 0.87).

Conclusions:

  • A geriatric assessment-based model significantly enhances prediction of 1-year mortality or functional decline in TAVR candidates.
  • This score offers a valuable tool for refining patient selection for TAVR.
  • Utilizing this score can help avoid unnecessary procedures in patients unlikely to benefit, thus preventing procedural futility.