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Related Experiment Video

Updated: Apr 17, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Citicoline Restores Endoplasmic Reticulum Homeostasis by Regulating Oxidative Stress Through CDO1 to Reverse Myopia

Peijuan Wu¹, Shan He¹, Li Zhang¹

¹The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.

Antioxidants & Redox Signaling

|April 15, 2026

Summary

This summary is machine-generated.

Citicoline reduces eye growth in myopia models by decreasing oxidative and endoplasmic reticulum stress. This compound targets cysteine dioxygenase 1 (CDO1), offering a potential strategy for myopia control.

Keywords:

CDO1 citicoline endoplasmic reticulum stress myopia oxidative stress scleral remodeling

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Last Updated: Apr 17, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

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Published on: April 3, 2016

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

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Published on: July 24, 2020

Area of Science:

Ophthalmology
Cell Biology
Biochemistry

Background:

Myopia progression is linked to oxidative and endoplasmic reticulum (ER) stress.
Understanding the molecular mechanisms underlying myopia is crucial for developing effective treatments.

Purpose of the Study:

To investigate if citicoline can alleviate ER stress in myopia by modulating oxidative stress.
To identify the molecular pathways through which citicoline exerts its effects in myopia.

Main Methods:

Utilized a form-deprivation myopia model in guinea pigs.
Employed a hypoxia-induced model in human scleral fibroblasts.
Conducted transcriptomic profiling to identify key molecular targets.

Main Results:

Citicoline downregulated cysteine dioxygenase 1 (CDO1) expression.
Increased glutathione levels and reduced reactive oxygen species (ROS) were observed.
Mitigation of oxidative and ER stress led to reduced axial elongation and extracellular matrix remodeling.

Conclusions:

Citicoline alleviates ER stress via CDO1-mediated redox regulation, suggesting a role in myopia control.
The findings provide preclinical mechanistic insights into citicoline's potential to delay myopia progression.
CDO1 is identified as a novel downstream effector linking cysteine metabolism to stress regulation in myopia.