Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
Protein Networks02:26

Protein Networks

3.0K
3.0K
Primary Active Transport01:29

Primary Active Transport

19.5K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
19.5K
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

11.8K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
11.8K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.9K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.9K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

4.5K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deciphering global patterns of marine microbial community assembly and network stability.

mSystems·2026
Same author

Tumor-infiltrating lymphocytes display prognostic signatures associated with chemotherapy response in TNBC patients.

iScience·2026
Same author

UNified FramewOrk for reguLatory Dynamics (UNFOLD): Dissecting robustness, plasticity, evolvability and canalisation of biological function.

PLoS computational biology·2026
Same author

Evaluating Metabolic Support in Pairwise Microbial Communities Using MetQuest.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Constraint-Based Modeling of Microbial Communities for Metabolite Production.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Genome-scale metabolic model guided metabolic flux analysis in the endophyte Alternaria burnsii NCIM1409.

Bioprocess and biosystems engineering·2026

Related Experiment Video

Updated: Apr 17, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.7K

Network hypermotifs in biological systems: structure, dynamics, and functional implications.

Moirangthem Sailash Singh1,2, Priyan Bhattacharya3, Karthik Raman4,5

  • 1Department of Data Science and AI, Wadhwani School of Data Science and AI, IIT Madras, Chennai, 600 036, India. sailashm@gmail.com.

NPJ Systems Biology and Applications
|April 15, 2026
PubMed
Summary

Biological networks feature complex structures like motifs and hypermotifs. Hypermotifs, assemblies of motifs, drive collective network properties and functions.

More Related Videos

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.8K
Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons
07:35

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Published on: October 18, 2017

8.6K

Related Experiment Videos

Last Updated: Apr 17, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.7K
Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.8K
Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons
07:35

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Published on: October 18, 2017

8.6K

Area of Science:

  • Systems biology
  • Network science
  • Bioinformatics

Background:

  • Biological networks, including gene and protein interactions, display intricate structural organization.
  • Recurring patterns known as motifs are fundamental units within these networks.
  • Higher-order assemblies, termed hypermotifs, emerge from motif combinations and interactions.

Purpose of the Study:

  • To review the concept and significance of hypermotifs in biological networks.
  • To explore the structure, dynamics, and functions associated with hypermotifs.
  • To discuss emergent patterns like motif clustering and generalizations within hypermotif frameworks.

Main Methods:

  • Literature review of biological network analysis.
  • Exploration of motif-based network organization.
  • Analysis of statistical significance in higher-order network assemblies.

Main Results:

  • Hypermotifs represent statistically significant, higher-order assemblies of biological network motifs.
  • These assemblies exhibit unique collective structural and functional properties.
  • Patterns such as motif clustering and motif generalizations are key characteristics of hypermotifs.

Conclusions:

  • Hypermotifs are crucial for understanding complex biological network organization beyond simple motifs.
  • Studying hypermotifs provides insights into the emergent behaviors and functions of biological systems.
  • Further research into hypermotif dynamics and generalizations can advance systems biology.