Association between serum uric acid levels and adverse pregnancy outcomes: A prospective cohort study

BackgroundEmerging evidence suggests that elevated serum uric acid levels may be associated with adverse pregnancy outcomes.ObjectivesTo investigate the association between serum uric acid levels and adverse pregnancy outcomes among pregnant women.Materials and methodsA prospective cohort study was conducted among 200 pregnant women attending Vinh Long General Hospital, including 100 women with hyperuricemia and 100 without hyperuricemia. Hyperuricemia was defined as a serum uric acid level >360 µmol/L. Pregnancy-, delivery-, and postpartum-related complications were recorded and compared between the two groups.ResultsThe mean maternal age was 25.06 ± 5.79 years. In the hyperuricemia group, 45.0% were primigravida, whereas 22.0% had multiple pregnancies. Adverse pregnancy outcomes were more frequent in women with hyperuricemia than in those without hyperuricemia (28.0% vs. 15.0%; odds ratio = 2.20; 95% confidence interval: 1.09-4.44). Within the hyperuricemia group, smoking was more common among women who developed complications than among those without complications (42.9% vs. 18.1%), along with lower platelet counts and higher creatinine levels (p < 0.05). Multivariable logistic regression analysis identified alcohol consumption (odds ratio = 3.85), serum creatinine (odds ratio = 1.19), and hyperuricemia (odds ratio = 1.65) as independent predictors of adverse pregnancy outcomes (p < 0.05).ConclusionHyperuricemia was independently associated with an increased risk of adverse pregnancy outcomes.