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Injectable grafts for hard tissue engineering: current trends and future perspectives.

Rajeev Ranjan1, Vikash Kumar1, Ayush Katyayan1

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Gopal Narayan Singh University, Sasaram, India.

Drug Development and Industrial Pharmacy
|April 16, 2026
PubMed
Summary

Injectable bone grafts offer a minimally invasive solution for bone regeneration. Recent material and technique advancements improve efficacy, though challenges in mechanical strength and scalability persist for widespread clinical use.

Keywords:
In situ hardening injectable scaffoldsbone tissue engineeringdiamond conceptgene deliveryosteoconductionosteoinduction

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Injectable bone grafts are a promising minimally invasive option for bone tissue regeneration.
  • They offer adaptability for complex anatomical defects, improving delivery of cells and bioactive agents.

Purpose of the Study:

  • To review the latest developments in injectable bone graft technologies.
  • To explore their clinical applications, material innovations, and associated challenges.

Main Methods:

  • Systematic review of recent studies on injectable bone grafts.
  • Examination of advancements in biomaterials, 3D printing, nanotechnology, and therapeutic agent incorporation.

Main Results:

  • Novel biomaterials (calcium phosphates, hydrogels, polymers) enhance cell interactions and bone growth.
  • 3D printing and nanotechnology improve graft precision and performance.
  • Incorporation of growth factors, stem cells, and antimicrobials boosts healing and reduces infection risk.

Conclusions:

  • Injectable bone grafts show enhanced applicability in bone regeneration due to recent innovations.
  • Overcoming challenges in mechanical strength, regulation, and scalability is key for broader clinical translation.