Loneliness is linked to psychological pain in both euthymic patients and healthy controls: a cross-sectional study

The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
Neuroticism and...

The need for affiliation is a fundamental human motive that drives individuals to form and maintain interpersonal relationships. This universal drive varies in intensity among individuals due to genetic predispositions and life experiences, shaping it into a relatively stable personality trait. Social inclusion enhances emotional well-being by fulfilling the need for affiliation, whereas social exclusion leads to distress, negative emotions, and cognitive impairments.Psychological and Emotional...

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.