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[How I investigate primary aldosteronism].

Maxime Coenen1, Laurent Vroonen2, Denis Henroteaux3

  • 1Faculté de Médecine, ULIège, Belgique.

Revue Medicale De Liege
|April 16, 2026
PubMed
Summary
This summary is machine-generated.

Primary aldosteronism (PA), a common cause of secondary hypertension, is often underdiagnosed. Early diagnosis and tailored management are crucial for better outcomes and preventing complications.

Keywords:
AdrenalectomyAldosteronArterial hypertensionPrimary aldosteronismSecondary hypertension

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Area of Science:

  • Endocrinology
  • Cardiology
  • Nephrology

Background:

  • Primary aldosteronism (PA) is an underdiagnosed cause of secondary hypertension (HTN).
  • PA can present with diverse clinical manifestations, including cardiac and refractory hypertension.
  • Prompt diagnosis and management are essential for patient outcomes.

Purpose of the Study:

  • To highlight the varied clinical presentations of primary aldosteronism.
  • To emphasize the importance of a structured diagnostic approach for PA subtypes.
  • To advocate for systematic screening of primary aldosteronism.

Main Methods:

  • Case report of two patients with primary aldosteronism.
  • Review of clinical presentations and diagnostic challenges.
  • Discussion of management strategies based on PA subtype.

Main Results:

  • Case 1 presented with left ventricular hypertrophy.
  • Case 2 presented with refractory hypertension.
  • Both cases underscore the diagnostic variability of PA.

Conclusions:

  • A structured diagnostic approach is vital for identifying PA subtypes.
  • Early diagnosis of PA improves blood pressure control and prevents complications.
  • Systematic screening for PA is needed due to its prevalence and underdiagnosis.