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Case Report: Fluoxetine-induced leucocytoclastic vasculitis.
Yanhua Qin1, Jiashu Yao1, Xiaoyun Jiang2
1Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Frontiers in Psychiatry
|April 16, 2026
Summary
Fluoxetine, an SSRI antidepressant, can cause delayed leukocytoclastic vasculitis (LCV). Cross-reactivity between SSRIs occurred, but switching to an SNRI (venlafaxine) resolved the rash.
Area of Science:
- Pharmacology
- Dermatology
- Psychiatry
Background:
- Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for generalized anxiety disorder (GAD).
- Cutaneous adverse reactions to SSRIs, though uncommon, can manifest as vasculitis.
- Delayed-onset drug reactions can occur even after prolonged periods of uneventful treatment.
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