Deaminative methylselenation of anlines with PhSO2SeCH3
Limei Wang1, Bo Zhang2, Yan Yan3
1Pharmaceutical Management Department, Jilin FAW General Hospital, Changchun, China.
Abstract:
Herein, we present a method for methylselenation of aryldiazonium salts that does not require metals or acids, achieved by directly transforming an amino group into a methylseleno group. This strategy is compatible with diverse anilines and facilitates rapid late-stage methylselenation of key pharmaceuticals and their derivatives, clearly demonstrating the utility of PhSO2SeCH3 as a methylselenation reagent. Mild reaction conditions proceed efficiently at a 100 mmol scale, allowing double methylselenation of anilines and concise construction of aryl-SeCD3.
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