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Turmeric Polymer Fiber Mats (T-PFMs): Solution Blow Spun Turmeric/PLGA Composites as a Comprehensive Wound Care
Kishan Kalluraya Yogesh1,2, Shannon Killen1, Andrew Mancuso1,2
1Department of Chemistry, The College of Staten Island, City University of New York, 2800 Victory Blvd, Staten Island, New York 10314, United States.
ACS Applied Polymer Materials
|April 16, 2026
Summary
Researchers developed bioresorbable turmeric/PLGA polymer fiber mats (PFMs) for advanced wound care. These turmeric-infused PFMs accelerate wound healing and possess hemostatic properties, offering a novel natural wound remedy.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Natural Product Chemistry
Background:
- Turmeric is a natural compound with historical use in wound healing.
- Developing advanced wound care materials requires biocompatible and effective components.
- Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for biomedical applications.
Purpose of the Study:
- To develop a bioresorbable wound care biomaterial using turmeric and PLGA.
- To optimize the formulation and production of turmeric/PLGA polymer fiber mats (PFMs).
- To evaluate the efficacy of turmeric-loaded PFMs in wound healing and hemostasis.
Main Methods:
- Solution blow-spinning technique using a siphon-fed airbrush to create ultrafine polymer fiber mats.
- Dynamic mechanical analysis and surface wettability tests to determine optimal turmeric loading (0.5% w/v).
- In vitro antimicrobial testing against *Escherichia coli* and *Staphylococcus aureus*.
- In vivo evaluation using a murine skin excisional wound model and a mouse tail-vein amputation bleeding model.
Main Results:
- Optimized turmeric/PLGA PFMs demonstrated effective inhibition of bacterial growth.
- PFMs promoted approximately 30% faster wound contraction and enhanced re-epithelialization.
- Histological analysis revealed well-organized, mature collagen deposition in healed wounds.
- Pilot studies indicated potential hemostatic capabilities of the turmeric-loaded PFMs.
Conclusions:
- Turmeric/PLGA PFMs represent a promising bioresorbable platform for comprehensive wound care.
- The developed material integrates antimicrobial, pro-healing, and hemostatic properties.
- This work establishes a foundation for a novel, turmeric-based wound dressing.
