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Updated: Apr 17, 2026

Three-Dimensional 3D Tumor Spheroid Invasion Assay
Published on: May 1, 2015
Integrin β3: structural functions, tumour microenvironment regulatory roles and targeted intervention strategies
Lianyi Peng1, Fuxian Liu2, Yue Yang1
1Key Laboratory of Environmental Ecology and Population Health in Northwest Minority Areas, State Ethnic Affairs Commission, Northwest University for Nationalities, Lanzhou, Gansu, China.
None:
Integrin β3 (ITGB3) functions as a pivotal transmembrane receptor mediating bidirectional signalling between cells and the extracellular matrix within the tumour microenvironment (TME). Dysregulated ITGB3 expression activates downstream pathways such as FAK/PI3K-Akt/mTOR, orchestrating core malignant processes including invasion, metastasis, angiogenesis, immune evasion, and autophagy modulation. Beyond its mechanistic roles, ITGB3 serves as a valuable biomarker for early diagnosis and prognostic assessment. Therapeutic strategies targeting ITGB3 encompass small-molecule inhibitors, monoclonal antibodies, and emerging Traditional Chinese Medicine (TCM) formulations, which offer unique multi-component regulatory advantages. This review systematically elucidates the structure-function relationship of ITGB3, its multidimensional regulatory mechanisms in tumour progression, and current targeted intervention strategies. Ultimately, we aim to provide theoretical insights for establishing ITGB3-guided precision medicine and integrated treatment systems.
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