Translational Geroscience Strategies for Delaying Multimorbidity

Area of Science:

• Gerontology and regenerative medicine, focusing on the biology of aging.

Background:

• Global aging populations increase the burden of chronic age-related diseases.
• Aging is increasingly viewed as a modifiable risk factor, not an inevitable decline.
• Current medical approaches often treat individual diseases rather than aging itself.

Purpose of the Study:

• To review advances in geroscience for modifying aging.
• To explore interventions targeting conserved aging drivers.
• To discuss strategies for extending healthspan and compressing morbidity.

Main Methods:

• Review of current geroscience literature and emerging interventions.
• Exploration of biological drivers of aging: genomic instability, epigenetic dysregulation, mitochondrial dysfunction, stem cell exhaustion.
• Discussion of innovative strategies like senolytics and epigenetic reprogramming.

Main Results:

• Geroscience offers potential to delay multiple age-related diseases concurrently.
• Senolytics and epigenetic reprogramming show promise for extending healthspan.
• Challenges include inter-species efficacy, reprogramming safety, and ethical considerations.

Conclusions:

• A paradigm shift towards targeting aging mechanisms is needed.
• Precision-based approaches and advanced tools (AI, organ-on-a-chip, multiomics) can redefine healthy aging.
• Integrating mechanistic discoveries into clinical practice is crucial for resilience and vitality in aging.