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Risks of Serious Adverse Events Associated With Non-Steroidal Anti-Inflammatory Drugs in Orthopaedic Surgery. A
Shaheer Bukhari1, Morten F Leth1, Christina C W Laursen1
1Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Acta Anaesthesiologica Scandinavica
|April 16, 2026
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) show no significant difference in serious adverse events compared to placebo for orthopedic surgery patients. However, the evidence is of very low certainty, requiring more research to confirm findings.
Area of Science:
- Orthopaedic Surgery
- Pharmacology
- Evidence-Based Medicine
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief after surgery.
- Concerns exist regarding potential serious adverse events associated with NSAID use.
- This study focuses on NSAID risks in patients undergoing orthopaedic surgery.
Conclusions:
- No clear difference in serious adverse events was found between NSAIDs and placebo in adult orthopaedic surgery patients.
- The current evidence is insufficient to draw definitive conclusions due to low certainty and high risk of bias in available studies.
- Further high-quality research is needed to establish the safety profile of NSAIDs in this patient population.
