Assessment of Indications for Percutaneous Coronary Intervention: A Multicenter Analysis after the Diagnosis of Chronic Coronary Syndrome
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Updated: Apr 17, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Uwe Zeymer1,2,3, Natalia Kelsch4, Karl Werdan2,5
1Institute for Myocardial Infarction Research Ludwigshafen
Insights
Quality of percutaneous coronary intervention (PCI) indications for chronic coronary syndrome needs improvement. Peer review revealed that while most PCI indications adhered to guidelines, more frequent ischemia testing is recommended for better patient outcomes.
Area of Science:
- Cardiology
- Health Services Research
- Quality Improvement
Background:
- Percutaneous coronary intervention (PCI) is a common procedure in Germany, with half of cases involving patients with chronic coronary syndrome.
- Limited data exists on the decision-making quality for PCI indications in this patient population.
Purpose of the Study:
- To evaluate the adherence to guidelines for percutaneous coronary intervention (PCI) indications in patients with chronic coronary syndrome.
- To identify areas for improvement in the decision-making process for elective PCI.
Main Methods:
- A peer review of PCI indications was conducted on-site in 16 German hospitals.
- 441 assessment forms from randomly selected patients with chronic coronary syndrome were analyzed.
Main Results:
- Over half of the patients (52.2%) presented with typical chest pain; a significant portion also experienced dyspnea.
- Most PCIs were performed for symptomatic patients with proven ischemia or severe stenosis (>90%).
- Guideline adherence for PCI indications was observed in 73.7% of cases, with 24.1% being questionable and 2.2% absent.
Conclusions:
- Elective PCI indications show a need for enhanced adherence to current German and international guidelines.
- Increased utilization of non-invasive or invasive ischemia testing is crucial.
- Peer review is essential for assessing and improving the quality of interventional procedure indications.
Background:
Percutaneous coronary intervention (PCI) is performed 300 000 times a year in Germany. Half of these procedures involve patients with chronic coronary syndrome. Little information is available on the quality of decision-making about the indication for PCI in this patient group.
Methods:
The Center for Health Services Research of the German Cardiac Society (Zentrum für kardiologische Versorgungsforschung der Deutschen Gesellschaft für Kardiologie - Herz- und Kreislaufforschung e.V., DGK-ZfKVF), in collaboration with the Initiative on Quality in Medicine (Initiative Qualitätsmedizin e.V., IQM) carried out this study, in which the indication for PCI in randomly selected patients with chronic coronary syndrome was reviewed by peers on site.
Results:
441 assessment forms from 16 hospitals were included in the study. More than half of the patients (52.2%) had typical chest pain, 20.1% had mainly dyspnea, 17.7% had chest pain and dyspnea, and 10% had no symptoms. Three-quarters had symptoms or ischemia despite optimal drug treatment. Most patients were treated for clinical symptoms and proven ischemia or stenosis of more than 90%. In 11% of patients, the indication was complete revascularization as a staged procedure after a prior myocardial infarction treated with PCI. 73.7% of indications for PCI were judged to be in adherence to the guidelines; guideline adherence was judged to be questionable in 24.1% and to be absent in 2.2%.
Conclusion:
These data on the quality of indications for elective PCI reveal a need for improvement in adherence to the recommendations of the current German and international guidelines. In particular, the non-invasive or invasive proof of ischemia should be performed more frequently. These findings underscore the importance of peer review of indications for interventional procedures.
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