Related Experiment Video

Updated: Apr 17, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K

Incidence and Early-Life Risk Factors for Food Allergy in a Spanish Birth Cohort

Jorge García-Ezquiaga1, Patricia Torija-Berzal1, Sergio Quevedo-Teruel1

  • 1Pediatric Department, Severo Ochoa University Hospital, Leganés, Madrid, Spain.

Acta Paediatrica (Oslo, Norway : 1992)
|April 16, 2026
PubMed

Insights

Food allergy affects 7.2% of children by age 4. Key risk factors include atopic dermatitis for IgE-mediated allergies and early-life exposures for non-IgE-mediated forms.

Area of Science:

  • Pediatrics
  • Allergology
  • Epidemiology

Background:

  • Rising prevalence of food allergies in children.
  • Need to understand early childhood incidence and risk factors.

Purpose of the Study:

  • Determine cumulative incidence of food allergy in early childhood.
  • Identify associated risk factors for food allergy.

Main Methods:

  • Prospective birth cohort study of 1006 newborns in Spain.
  • Follow-up to 4 years of age with data collection at birth and via interviews.
  • Diagnostic methods included skin prick testing, IgE measurement, and oral food challenges.

Main Results:

  • Cumulative incidence of food allergy was 7.2% by age 4.
  • IgE-mediated food allergy linked to bronchospasm, atopic dermatitis, maternal asthma, and paternal allergic rhinitis.
  • Non-IgE-mediated food allergy associated with proton-pump inhibitor use, no daycare, and early atopic dermatitis.

Conclusions:

  • Food allergy impacts 7.2% of children by age 4 in this Spanish cohort.
  • Atopic dermatitis is a primary risk factor for IgE-mediated food allergy.
  • Modifiable early-life exposures correlate with non-IgE-mediated food allergy.
Abstract

Keywords:
IgE‐mediated allergyatopic dermatitisfood allergynon‐IgE‐mediated allergyoral food challengerisk factors

More Related Videos

Basophil Activation Test for Allergy Diagnosis07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

10.0K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.9K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
34.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
224
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.8K
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
2.4K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
45