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Secondary Spinal Cord Injury llI: Pathophysiology

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Updated: Apr 18, 2026

In Vivo Telemetry to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in Spinal Cord Injury Rat Models

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Temporal Biomarker Profiles Following Non-Surgical Spinal Cord Concussion

Taylor M Dickson¹, Anastasiya Loos¹, Malaika Amin¹

¹Deparment of Biomedical Research, Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA.

Journal of Molecular Neuroscience : MN

|April 16, 2026

Summary

No abstract available in PubMed .

Keywords:

Back pain Biomarkers Concussion Spinal cord injury

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