Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

88
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
88
T Cell Types and Functions01:24

T Cell Types and Functions

3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

102
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
102
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

2
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
2
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.3K
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

2
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway.

Cellular and molecular life sciences : CMLS·2026
Same author

CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells circumstantially initiate transplant rejection through CXCL15/neutrophil axis.

Communications biology·2026
Same author

Beyond pathogens: a narrative review of the immunological nexus of damage-associated molecular patterns and inflammasome activation in sterile AECOPD.

Frontiers in immunology·2026
Same author

Chinese herbal formulas as adjuncts to antihistamines in chronic spontaneous urticaria: a network meta-analysis of efficacy, recurrence, and safety.

Frontiers in pharmacology·2026
Same author

Disentangling environmental and disease-specific signatures in the gut microbiome of psoriasis: discovery of Fimenecus sp. as a novel biomarker and characterization of the gut virome.

Journal of translational medicine·2026
Same author

Effect of Intermittent Pneumatic Compression Device on Coagulation and Fibrinolysis and Distal Deep Venous Thromboembolism in Patients Undergoing Gynaecology Laparoscopic Surgery During Perioperative Care: A Retrospective Cohort Study.

International journal of women's health·2026

Related Experiment Video

Updated: Apr 18, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.2K

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue-Resident Memory T Cells via Altering

Chun-Ling Liang1,2, Yuchao Chen1,2, Chuanjian Lu1,2

  • 1Section of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 16, 2026
PubMed
Summary

High humidity worsens psoriasis relapse by increasing skin T cells via IL-15Rα on keratinocytes, linked to Staphylococcus nepalensis. Antibiotic treatment helped alleviate symptoms.

Keywords:
humiditykeratinocytepsoriasisskin microbiometissue‐resident memory T cell (TRM)

More Related Videos

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.9K
Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation
02:36

Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation

Published on: March 8, 2024

1.8K

Related Experiment Videos

Last Updated: Apr 18, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.2K
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.9K
Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation
02:36

Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation

Published on: March 8, 2024

1.8K

Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • Psoriasis recurrence is a significant clinical challenge.
  • Environmental humidity's role in psoriasis relapse is unclear.
  • Understanding triggers for psoriasis relapse is crucial.

Purpose of the Study:

  • To investigate the impact of high humidity on psoriasis relapse.
  • To elucidate the underlying mechanisms involving T cells and keratinocytes.
  • To identify potential therapeutic targets for recurrent psoriasis.

Main Methods:

  • Utilized mouse models of psoriasis relapse.
  • Exposed mice to high humidity conditions.
  • Analyzed skin-resident memory CD8+ T (T_RM) cell populations.
  • Investigated the role of IL-15Rα on keratinocytes.
  • Assessed the contribution of Staphylococcus nepalensis and its metabolites.
  • Conducted in vitro experiments with keratinocytes and bacterial cultures.
  • Evaluated the efficacy of mupirocin treatment.
  • Studied humanized mouse models.

Main Results:

  • High humidity exacerbated psoriasis recurrence by increasing skin T_RM cells.
  • This effect was mediated by IL-15Rα upregulation on keratinocytes.
  • Staphylococcus nepalensis colonization or its metabolite ADMA increased IL-15Rα and T_RM cells, worsening relapse.
  • Mupirocin treatment alleviated recurrent psoriasis.
  • In vitro, S. nepalensis upregulated keratinocyte IL-15Rα, promoting T_RM cell formation.
  • High humidity aggravated psoriatic lesions in humanized mice.

Conclusions:

  • High humidity exacerbates psoriasis relapse through IL-15Rα-dependent keratinocyte activation and subsequent CD8+ T_RM cell formation.
  • Cutaneous Staphylococcus nepalensis and its metabolite ADMA play a key role in this humidity-induced mechanism.
  • Targeting IL-15Rα or S. nepalensis may offer new therapeutic strategies for recurrent psoriasis.