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Updated: Apr 18, 2026

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Cardiovascular-Related Maternal Mortality.

Lisa D Levine1, Catherine Klammer, Jennifer Lewey

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Obstetrics and Gynecology
|April 16, 2026
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Summary
This summary is machine-generated.

Cardiovascular disease (CVD) is a major cause of maternal death, especially in Black women. Optimizing preconception and postpartum care, alongside risk assessment, is crucial for managing CVD during pregnancy and reducing mortality.

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Area of Science:

  • Cardiology
  • Maternal Health
  • Public Health

Background:

  • Cardiovascular disease (CVD) is the primary cause of pregnancy-related mortality in the U.S.
  • Black women experience disproportionately high rates of CVD-related maternal deaths.
  • Key risk factors include hypertension, diabetes, dyslipidemia, and obesity.

Purpose of the Study:

  • To review major contributors to cardiovascular-related maternal deaths.
  • To emphasize the importance of preconception and postpartum care for cardiovascular risk management.
  • To discuss evidence-based approaches for managing CVD in reproductive-aged women.

Main Methods:

  • Review of evidence-based approaches for cardiovascular risk management in reproductive-aged women.
  • Discussion of preconception counseling and risk assessment tools (e.g., modified WHO 2.0 classification).
  • Analysis of diagnostic tools (e.g., NT-proBNP testing) for differentiating cardiac symptoms from pregnancy-related conditions.

Main Results:

  • Prepregnancy optimization of risk factors mitigates cardiovascular risk during pregnancy.
  • Validated tools and specific testing aid in accurate CVD assessment and diagnosis.
  • Evidence-based management strategies exist for conditions like cardiomyopathy, myocardial infarction, and hypertensive disorders of pregnancy.

Conclusions:

  • Standardized perinatal CVD risk assessment algorithms are essential.
  • Postpartum remote monitoring programs can help address disparities.
  • Integrated preconception and postpartum care are vital for reducing maternal CVD mortality.