An undescribed stilbene from macaranga aenigmatica whitmore and its anticancer activity
Tjitjik Srie Tjahjandarie1, Widya Eko Susilowati1, Aji Setyo Utomo1
1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Abstract:
An undescribed stilbene, macaenigmaticin A (1), together with two known compounds, mappain (2) and macapruinosin A (3), were isolated from Macaranga aenigmatica Whitmore leaves. The structure of 1 was determined from a combination of ESI-HRMS and NMR spectra. Cytotoxicity was tested against the HeLa (cervical cancer) and P-388 (murine leukaemia) cell lines. Macaenigmaticin A (1) and macapruinosin A (3) were potent against P-388 cells, with IC50 values of 1.15 and 1.53 µg/mL, respectively. Stibenes 1-3 were inactive against HeLa cells.
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