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Canine mammary carcinoma: An update
Oscar Hernán Rodríguez-Bejarano1, Lucía Botero2, Giovanni Vargas Hernández2
1Health Sciences Faculty, Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A), Calle 222#55-37, Bogotá 111166, Colombia; FIDIC Group, Fundación para la Investigación Traslacional Manuel Elkin Patarroyo (FITMEP), Calle 44#58-05, Bogotá 111321, Colombia; PhD Programme in Biotechnology, Sciences Faculty, Universidad Nacional de Colombia, Carrera 45#26-85, Bogotá 111321, Colombia; Immunology and Translational Medicine Group, Medicine Faculty, Universidad Nacional de Colombia, Carrera 45#26-85, Bogotá 111321, Colombia.
Canine mammary carcinoma (CMC) is a common cancer in unspayed dogs, posing a significant veterinary challenge. Its similarity to human breast cancer makes canine mammary carcinoma a valuable animal model for cancer research.
Area of Science:
- Veterinary Medicine
- Oncology
- Comparative Pathology
Background:
- Canine mammary carcinoma (CMC) is the most frequent tumor in unspayed female dogs.
- CMC is a significant cause of mortality in canines.
- CMC shares biological and clinical similarities with human breast cancer (HBC).
Purpose of the Study:
- To provide a comprehensive review of canine mammary carcinoma.
- To highlight CMC as a relevant animal model for human breast cancer research.
- To consolidate information on CMC's clinical, pathological, epidemiological, and therapeutic aspects.
Main Methods:
- Literature review of canine mammary carcinoma.
- Analysis of clinical-diagnostic, histopathological, and clinicopathological data.
- Synthesis of information on carcinogenesis, metabolism, therapy, biomarkers, and prognosis.
Main Results:
- CMC presents diverse clinical and histopathological characteristics.
- Epidemiological features and carcinogenesis pathways are being elucidated.
- Therapeutic strategies, biomarkers, and prognostic factors are crucial for management.
Conclusions:
- Canine mammary carcinoma is a critical area of veterinary oncology.
- CMC serves as a valuable preclinical model for advancing human breast cancer research.
- Further understanding of CMC biology and treatment is essential for improving outcomes.
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