[A single-center study on the clinical characteristics of 15 cases of large granular lymphocytic leukemia]

This study retrospectively analyzed the clinical data of 15 patients diagnosed with large granular lymphocytic leukemia (LGLL) at the First Affiliated Hospital of Chongqing Medical University between January 2017 and December 2024. The median age was 50 years, and the main clinical manifestations included fatigue (73.3%), splenomegaly (46.7%), and lymphadenopathy (33.3%). None of the patients had autoimmune diseases. Laboratory examinations primarily demonstrated decreased hemoglobin levels (100%) and/or neutropenia (73.3%). The bone marrow smears showed an increase in lymphocyte proportion, and pure red cell aplasia was frequently observed. The typical immunophenotype was TCRαβ(+)TCRγδ(-)CD3(+)CD4(-)CD8(+)CD16(-)CD10(-)CD30(-)CD45RA(+)CD45RO(-)CD56(-)CD25(-), with monoclonal T-cell proliferation confirmed in all patients. Further, 8 patients demonstrated decreased complement C3 or C4 levels. The overall response rate of first-line immunosuppressive therapy for patients with LGLL was 85.7% (12/14) .