Related Experiment Video

Updated: Apr 18, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

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Competing gene regulatory networks drive naive and memory B cell differentiation

Pietro Demela1, Laura Esposito1, Pietro Marchesan1

  • 1Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.

Molecular Systems Biology
|April 16, 2026
PubMed
Summary

Human B cell differentiation involves distinct gene regulatory networks (GRNs) for naive and memory cells. Memory B cells favor plasma cell pathways, while naive cells diverge, impacting immune responses and autoimmunity.

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